MIF-1
CAS No. : 2002-44-0
(Synonyms: Pro-Leu-Gly-NH2; Melanostatin)
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| Cat. No. : | HY-107663 |
| M.Wt: | 284.35 |
| Formula: | C13H24N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)[1][2][3].
In Vitro:MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials[2].
In Vivo:MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA)[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats[3].
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