Kasugamycin (hydrochloride hydrate)
CAS No. : 200132-83-8
(Synonyms: Ksg (hydrochloride hydrate))
| Size | Price | Stock |
|---|---|---|
| 500mg | $40 | In-stock |
| 1g | $60 | In-stock |
| 5g | $150 | In-stock |
| 10g | $210 | In-stock |
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| Cat. No. : | HY-B1864B |
| M.Wt: | 433.84 |
| Formula: | C14H28ClN3O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 1.67 mg/mL (ultrasonic;warming;heat to 80°C);H2O : 25 mg/mL (ultrasonic) |
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models[1][2][3]. In Vitro: Kasugamycin (50-250 μg/mL) hydrochloride hydrate decreases mycobacterial mistranslation due to the indirect tRNA aminoacylation pathway[3]. In Vivo: Kasugamycin (400 mg/kg; i.m.; once daily for 2 weeks) hydrochloride hydrate enhances in vivo killing of M.tuberculosis by Rifampicin (10 mg/kg) in mouse model[3].
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