SKF 38393 (hydrobromide)
CAS No. : 20012-10-6
(Synonyms: (±)-SKF-38393 (hydrobromide))
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| Cat. No. : | HY-12237 |
| M.Wt: | 336.22 |
| Formula: | C16H18BrNO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].
In Vitro: SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].
In Vivo: SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
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