HTH-01-091
CAS No. : 2000209-42-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $380 | In-stock |
| 5mg | $880 | In-stock |
| 10mg | $1250 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-122665 |
| M.Wt: | 499.43 |
| Formula: | C26H28Cl2N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1].
IC50 & Target: IC50: 10.5 nM (MELK), 41.8 nM (DYRK3), 42.5 nM (RIPK2), 60.6 nM (PIM1), 108.6 nM (smMLCK), 632 nM (mTOR), 962 nM (PIK3CA), 1230 nM (CDK7), 1740 nM (GSK3A)[1]
In Vitro: HTH-01-091 (1 μM) selectively inhibits 4% of the kinases over 90%[1].
HTH-01-091 (0-10 μM, 1 h) is cell permeable and causes MELK degradation[1].
HTH-01-091 (0-10 μM, 3 day) exhibits minor antiproliferative effects in breast cancer cells[1].
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