ALX-5407 (hydrochloride)
CAS No. : 200006-08-2
(Synonyms: (R)-NFPS (hydrochloride))
| Size | Price | Stock |
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| 1mg | $75 | In-stock |
| 5mg | $158 | In-stock |
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| Cat. No. : | HY-10711A |
| M.Wt: | 429.91 |
| Formula: | C24H25ClFNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1]. In Vitro: ALX-5407 hydrochloride (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1]. ALX-5407 hydrochloride (50 nM) shows slow dissociation kinetics in QT6-1C cells[1]. In Vivo: ALX-5407 hydrochloride (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex[1].
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