JHU-083
CAS No. : 1998725-11-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $270 | In-stock |
| 5mg | $570 | In-stock |
| 10mg | $930 | In-stock |
| 25mg | $1767 | In-stock |
| 50mg | $2300 | In-stock |
| 100mg | $3000 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122218 |
| M.Wt: | 312.36 |
| Formula: | C14H24N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Ethanol : 133.33 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].
In Vivo: JHU-083 (1.82 mg/kg; PO; every other day for 12 days) ameliorates social avoidance behavior and anhedonia-like behavior induced by CSDS[1].
JHU-083 (1.82 mg/kg, PO) attenuates CSDS-induced increase in glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but not in the cerebellum. JHU-083 treatment suppresses the CSDS-induced upregulation of IL-1β and TNF-α expression[1].
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