GSK8814
CAS No. : 1997369-78-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $184 | In-stock |
| 5mg | $460 | In-stock |
| 10mg | $780 | In-stock |
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| Cat. No. : | HY-114204 |
| M.Wt: | 527.61 |
| Formula: | C28H35F2N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GSK8814 is a potent and selective ATAD2 bromodomain chemical probe and inhibitor (IC50 = 0.059 μM), with a binding constant pKd = 8.1 and a pKi = 8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 can be researched for cancer associated with ATAD2 bromodomain[1][2][3].
In Vitro:GSK8814 (Compound 16) (10 nM-1 μM) results in dose-dependent displacement[1].
GSK8814 (20 μM) has effects on colony formation and inhibits genes involved in cell cycle and division at high compound concentrations in LNCaP cells (IC50 = 2.7 μM)[1].
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