Lucidone

Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM)^[1][2]. In Vitro: Lucidone (10 μg/mL, 25 μg/mL; 1 h or 20 h) decreases the increase of TNF-α secretion (20 h) as well as PGE₂ production (1 h) in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (10 μg/mL, 25 μg/mL; 8 h) inhibits iNOS and COX-2 expression in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (10 μg/mL, 25 μg/mL; 1 h) reduces the levels of p65 and of the p50 subunits of NF-κB, and phosphorylated IKK in LPS-induced (1 μg/mL) RAW 264.7 macrophages^[1].
Lucidone (0-40 μM; 3 d) decreases the virus titer of DENV in Huh-7 cells infected with DENV^[2].
In Vivo: Lucidone (1 mg/kg; intracranial injection; 3 times for 1 week) significantly increases the survival rate and body weight of DENV-infected mice^[2].