Revaprazan
CAS No. : 199463-33-7
(Synonyms: SB 641257)
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| Cat. No. : | HY-121851 |
| M.Wt: | 362.44 |
| Formula: | C22H23FN4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Revaprazan (SB 641257) is reversible proton pump inhibitor. Revaprazan can inhibit gastric acid secretion and protect gastric mucosa. Revaprazan can inhibit IkappaB-alpha degradation as well as Akt inactivation, resulting in attenuation of H. pylori-induced COX-2 expression. Revaprazan can be used for the researches of infection and inflammmation, such as H. pylori-infected gastric inflammation and gastric ulcer[1][2].
In Vitro:Revaprazan (5-20 μM, 24 h) reduces H. pylori-stimulated COX-2 expression and activity in AGS cells[1].
Revaprazan (5-20 μM, 24 h) inhibits transcription activity of NF-κB in H. pylori-stimulated AGS cells[1].
Revaprazan (5-20 μM, 24 h) improves the retarded cell growth in H. pylori-stimulated AGS cells[1].
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