ML364
CAS No. : 1991986-30-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $83 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $225 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
| 500mg | $1180 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-100900 |
| M.Wt: | 517.54 |
| Formula: | C24H18F3N3O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2].
IC50 & Target: IC50: 1.1 μM (USP2)[1]
Kd: 5.2 μM (USP2)[1]
In Vitro: ML364 (5-20 μM; 24-48 hours) inhibits LnCAP and MCF7 cells viability in a dose-dependent manner[1].
ML364 (10 μM; 2-24 hours) reduces cyclin D1 protein levels in a time-, dose-, and proteasome-dependent manner in HCT116 cells and Mino cells[1].
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