Ziprasidone (mesylate trihydrate)
CAS No. : 199191-69-0
(Synonyms: CP-88059 (mesylate trihydrate))
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| Cat. No. : | HY-14542B |
| M.Wt: | 563.09 |
| Formula: | C22H31ClN4O7S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1]. In Vitro: Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current[2]. In Vivo: Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].
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