Cholesterol myristate
CAS No. : 1989-52-2
(Synonyms: Cholesteryl myristate; Cholesteryl tetradecanoate)
| Size | Price | Stock |
|---|---|---|
| 500mg | $35 | In-stock |
| 1g | $60 | In-stock |
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| Cat. No. : | HY-N2338 |
| M.Wt: | 597.01 |
| Formula: | C41H72O2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 3.33 mg/mL (ultrasonic) |
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. IC50 & Target:nAChR, GABAA receptor, Potassium Channel[3] In Vitro: Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].
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