Tranylcypromine (hydrochloride)
CAS No. : 1986-47-6
(Synonyms: SKF 385 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
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| 1g | $52 | In-stock |
| 5g | $63 | In-stock |
| 10g | $126 | In-stock |
| 25g | $314 | In-stock |
| 100g | $1162 | In-stock |
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| Cat. No. : | HY-17447A |
| M.Wt: | 169.66 |
| Formula: | C9H12ClN |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[1][2][3]. IC50 & Target:IC50: 20.7 μM ( LSD1), 2.3 μM (MAO A), 0.95 μM (MAO B)[2] In Vitro: Tranylcypromine hydrochlorid (50 μM-5 mM; 1 h or 12-14 h) inhibits histone and nucleosomal demethylation[1]. Tranylcypromine hydrochlorid (2 μM; 3 h) shows a specific derepression of OCT4 transcription[1]. Tranylcypromine hydrochlorid (0-100 μM; 15 min) shows IC50 values of 20.7, 2.3 and 0.95 μM for LSD1, MAO A and MAO B, respectively[2]. Tranylcypromine hydrochlorid (0-800 μM) shows Ki values of 242.7, 101.9 and 16 μM for LSD1, MAO A and MAO B, respectively[2]. In Vivo: Tranylcypromine hydrochlorid (3 mg/kg; i.p. once daily for 3 days) decreases LPS-mediated microglial activation and proinflammatory cytokine COX-2 and IL-6 levels in wild-type mice[3]. Tranylcypromine hydrochlorid (3 mg/kg; i.p. once daily for 7 days) down-regulates Aβ-mediate microglial activation in 5xFAD mice[3].
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