Icofungipen
CAS No. : 198022-65-0
(Synonyms: BAY 10-8888; PLD 118)
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| Cat. No. : | HY-106997 |
| M.Wt: | 141.17 |
| Formula: | C7H11NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1].
In Vitro:Icofungipen shows inhibitory effect on Candida species with MIC values of 16-64 μg/mL after 24-48 h[1].
Icofungipen shows MIC90 values of 8-32 μg/mL for 90% C. albicans[1].
In Vivo:Icofungipen (5-25 mg/kg; po; twice daily for 7 days) shows a dose-dependent protection against clinical isolates of C. albicans in a lethal model of infection in mice[1].
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