CRT0273750
CAS No. : 1979939-16-6
(Synonyms: IOA-289)
| Size | Price | Stock |
|---|---|---|
| 1mg | $37 | In-stock |
| 5mg | $88 | In-stock |
| 10mg | $139 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $428 | In-stock |
| 100mg | $645 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120797 |
| M.Wt: | 502.92 |
| Formula: | C25H22ClF3N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
CRT0273750 is an autotaxin (ATX) inhibitor and modulates LPA levels in plasm (IC50 = 0.014 μM). CRT0273750 can be used in ATX/LPA-dependent models of cancer[1].
IC50 & Target:IC50: 0.014 μM (plasma CRA)
In Vitro: CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM)[1].
CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM[1].
In Vivo: CRT0273750 (1 mg/kg; i.v.)has a moderate blood clearance, with value of 41 mL/min/kg[1].
CRT0273750 (10 mg/kg; oral administration) treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively[1].
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