Deschloroclozapine
CAS No. : 1977-07-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $64 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $210 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
| 1g | $1900 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-42110 |
| M.Wt: | 292.39 |
| Formula: | C18H20N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
IC50 & Target:Ki: 6.3 nM (hM3Dq), 4.2 nM (hM4Di)[2]
In Vitro: Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance[2].
In Vivo: Deschloroclozapine (0.3 mg/kg; intramuscularly) impairs working memory function in male rhesus macaques (aged between 5 and 6 years and weighing 5.5-7.9 kg)[3].
Deschloroclozapine (0.1 mg/kg; i.m) is effective at activating DREADD receptors in vivo and reversibly inducing behavioral effects in monkeys[3].
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