Sodium 2-mercaptoethanesulfonate

Sodium 2-mercaptoethanesulfonate (Mesnum) is a thiol-containing urinary tract protective agent and aldehyde scavenger that detoxifies acrolein via its thiol group to form an inert thioether excreted in urine, and competitively inhibits human myeloperoxidase, thereby mitigating Cyclophosphamide (HY-17420)-induced cytogenetic damage. Sodium 2-mercaptoethanesulfonate can be used for research on hemorrhagic cystitis^{[1][2][3][4][5][6][7][8][9]}. In Vitro:Sodium 2-mercaptoethanesulfonate (Mesna) (1-10 mM; 48 h) significantly attenuates cyclophosphamide-induced sister chromatid exchange and protects against cytotoxicity in concanavalin A-stimulated cultured human lymphocytes^[1].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M ± 0.1 M in H₂O) (1 mM) provides complete protection against acrolein-induced SCEs and cell lethality up to 40 μM in concanavalin A-stimulated cultured human lymphocytes, although it does not completely prevent cell cycle inhibition at the highest concentration^[1].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H₂O) (1 mM) completely protects human lymphocytes stimulated with concanavalin A against SCEs induced by 10 and 15 μM DEHP-CP and cytotoxicity up to 40 μM, and provides partial protection against SCEs at higher concentrations^[1].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H₂O) (1 mM) significantly reduces HY-
Polyacrylamide,Anion,Mw 18 million (PAM) (W115727B)-induced SCEs at concentrations of 0.0068 μM and above in concanavalin A-stimulated cultured human lymphocytes, but does not consistently protect against PAM-induced cytotoxicity^[1].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M ± 0.1 M in H₂O) (1 mM) significantly reduces the frequency of structural chromosomal aberrations induced by PAM at concentrations of 0.339 μM and above in concanavalin A-stimulated cultured human lymphocytes^[1].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H₂O) (300 μM; 24 h), when used as a co-treatment or 6 h pretreatment, provides complete neuroprotection against acrolein-induced cell death in SN56 cholinergic neurons^[4].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H₂O) increases cysteine levels in SN56 cholinergic neurons^[4]. In Vivo:Sodium 2-mercaptoethanesulfonate (Mesna) (150 mg/kg; i.p.; single administration; 60 min) depletes serum cysteine to 17% of the control group and significantly reduces serum total homocysteine, without significantly altering serum SAM or SAH^[6].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M±0.1 M in H₂O) (80 mg/kg; i.p.; 1 h before acrolein) or (2 mg/bladder; intravesical; simultaneously with acrolein) significantly inhibits acrolein-induced hemorrhagic cystitis in mice^[8].
2-Mercaptoethanesulfonic acid (ampule, 3.0 M ± 0.1 M in H₂O) (40 mg/kg; i.p.; administered at 0, 4, and 8 h after IFO) almost completely eliminates IFO-induced hemorrhagic cystitis in rats^[9].