N-Acetyl-R-leucine
CAS No. : 19764-30-8
(Synonyms: N-Acetyl-D-leucine)
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| 500g | $173 | In-stock |
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| Cat. No. : | HY-Y1080 |
| M.Wt: | 173.21 |
| Formula: | C8H15NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N-Acetyl-R-leucine is an amino-protecting group N-substituted chiral amino acid. N-Acetyl-R-leucine is a PepT1 and MCT1 inhibitor with IC50 of 0.74 and 11 mM, respectively. N-Acetyl-R-leucine can be used for LysoTracker signaling studies[1][2][3][4].
In Vitro:N-Acetyl-R-leucine is not a substrate of LAT1 and PepT1, but is an inhibitor of PepT1 with an IC50 of 0.74 mM[2].
N-Acetyl-R-leucine is a substrate of MCT1 with a Km of 1.0 mM, and an inhibitor of MCT1 with an IC50 of 11 mM[2].
N-Acetyl-R-leucine (1-5 mM; 7 days) shows no apparent dose-dependent effect on LysoTracker signaling in NPC1-deficient Chinese hamster ovary cells, but is statistically significant at higher concentrations (5 mM)[3].
In Vivo:N-Acetyl-R-leucine (24 mg per rat; i.v.; once a day) has no significant effect on the compensation of nystagmus and postural imbalance scores in rats[4].
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