cyclo(RLsKDK)
CAS No. : 1975145-82-4
(Synonyms: BK-1361)
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $340 | In-stock |
| 10mg | $545 | In-stock |
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| Cat. No. : | HY-P1676 |
| M.Wt: | 727.85 |
| Formula: | C31H57N11O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer[1].
In Vitro:cyclo(RLsKDK) promotes ADAM8 activation and CD23 shedding with IC50 values of 120 nM and 182 nM, respectively[2].
cyclo(RLsKDK) (200 nM; 0-120 h) increases activity of pro-ADAM8[2].
cyclo(RLsKDK) (200 nM and 500 nM; 12 h) promotes the growth of Panc1_ctrl and Panc1_A8 cells[2].
cyclo(RLsKDK) (500 nM) causes ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells[2].
In Vivo:cyclo(RLsKDK) (10 µg/g; i.p.; once weekly for 4 weeks) significantly reduces tumour load in mice which implant Panc1_ctrl or Panc1_A8 cells. cyclo(RLsKDK) improves the survival rate of pancreatic ductal adenocarcinoma (PDAC) mice, reduces soluble ADAM8 (sADAM8) content, pERK1/2 activation, and PDAC metastasis in the liver and lungs of PDAC mice[2].
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