PQ401
CAS No. : 196868-63-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $115 | In-stock |
| 50mg | $350 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-13686 |
| M.Wt: | 341.79 |
| Formula: | C18H16ClN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 14.29 mg/mL (ultrasonic);H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis[1].
IC50 & Target: IGF-IR; apoptosis[1]
In Vitro: PQ401 (1, 5, 10, 25, and 50 μM; 3 days) inhibits proliferation of cultured MCF-7 cells grown in serum or IGF-I in MCF-7 cells[1].
Twenty-four hours of treatment with 15 μM PQ401 induces caspase-mediated apoptosis[1].
PQ401 inhibits autophosphorylation of the IGF-IR kinase domain at concentrations <100 nM, with an IC50 <1 μM.
In Vivo: PQ401 (50 or 100 mg/kg; i.p.; thrice a week) results in a significant dose-dependent reduction in tumor growth over the course of the study. PQ401 reduces the growth rate of MCNeuA cells implanted into mice[1].
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