(S)-10-Hydroxycamptothecin
CAS No. : 19685-09-7
(Synonyms: 10-HCPT; 10-Hydroxycamptothecin)
| Size | Price | Stock |
|---|---|---|
| 100mg | $35 | In-stock |
| 250mg | $79 | In-stock |
| 500mg | $135 | In-stock |
| 1g | $230 | In-stock |
| 5g | $505 | In-stock |
| 10g | $755 | In-stock |
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| Cat. No. : | HY-N0095 |
| M.Wt: | 364.35 |
| Formula: | C20H16N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].
In Vitro:(S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase[2].
(S)-10-Hydroxycamptothecin induces differentiation, down-regulates nuclear antigen (PCNA) and up-regulates wild-type protein p53 in Hep G2 cells[2].
(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC50 of 1.15 μM[1].
In Vivo:(S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) against L1210 leukemia in mice is tested. At the optimal dose (15 mg/kg), (S)-10-Hydroxycamptothecin has a 71% increase in life span (ILS)[1].
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