GW7845
CAS No. : 196809-22-0
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| Cat. No. : | HY-121746 |
| M.Wt: | 500.54 |
| Formula: | C29H28N2O6 |
| Purity: | >98 % |
| Solubility: |
GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].
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