Panaxadiol
CAS No. : 19666-76-3
(Synonyms: 20(R)-Panaxadiol)
| Size | Price | Stock |
|---|---|---|
| 5mg | $96 | In-stock |
| 10mg | $120 | In-stock |
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| Cat. No. : | HY-N0596 |
| M.Wt: | 460.73 |
| Formula: | C30H52O3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 20 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].
In Vitro: Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells[1].
Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells[1].
In Vivo: Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model[1].
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