Oxadiazon
CAS No. : 19666-30-9
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
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| Cat. No. : | HY-B1880 |
| M.Wt: | 345.22 |
| Formula: | C15H18Cl2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Oxadiazon is an orally active herbicide. Oxadiazon reduces hepatic cytochrome P450 levels. Oxadiazon increases palmitoyl CoA oxidase, acetyl carnitine transferase, and hepatic ALAS activity. Oxadiazon induces hepatomegaly and experimental porphyria. Oxadiazon controls weeds. Oxadiazon may be used in neurodegenerative disease research[1][2][3][4][5].
In Vitro:Oxadiazon (7.81 μM; 1-24 h) inhibits ALDH2 expression/activity, increases ACYP2 expression/activity and FGF2/BDNF-induced neuronal differentiation of human striatal precursor (HSP) cells[3].
Oxadiazon (2.5-100 μM; 72 h) induces dose-dependent increases in palmitoyl CoA oxidase and acetyl carnitine transferase activities in rat hepatocytes[5].
In Vivo:Oxadiazon (1000 ppm; p.o. via diet; 6 days) induces experimental porphyria in male ICR mice and Wistar rats, with elevated fecal/urinary/biliary porphyrins, increased hepatic ALAS activity, and decreased hepatic cytochrome P450 levels[4].
Oxadiazon (20-500 mg/kg body wt/day; p.o.; once daily; 14 days) induces dose-dependent hepatomegaly, peroxisome proliferation, and increased peroxisomal enzyme activities in male Sprague-Dawley CD rats[5].
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