Falnidamol
CAS No. : 196612-93-8
(Synonyms: BIBX 1382)
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $211 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $535 | In-stock |
| 100mg | $750 | In-stock |
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| Cat. No. : | HY-10322 |
| M.Wt: | 387.84 |
| Formula: | C18H19ClFN7 |
| Purity: | >98 % |
| Solubility: | DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C) |
Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity[1][2].
In Vitro: Falnidamol (BIBX 1382) demonstrates antiproliferative activity in mitogenic assays performed with KB cells[2].
In Vivo: Falnidamol (BIBX 1382; p.o.; 10 mg/kg/day; 16 days) completely suppressed tumor growth of human A431 xenografts with respective a T/C value of 15% after 2 weeks of treatment[2].
Falnidamol (50 mg/kg/day for 2 weeks) results in dephosphorylation of the EGF receptor in A431 xenograft-bearing mice[2].
With Falnidamol (p.o.; 10 mg/kg/day; 16 days), the C4h is 2222 nM and the C24h is 244 nM[2].
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