YPC-22026
CAS No. : 1964457-41-7
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| Cat. No. : | HY-120264 |
| M.Wt: | 331.25 |
| Formula: | C16H8F3N3O2 |
| Purity: | >98 % |
| Solubility: |
YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities[1].
In Vitro:YPC‐22026 (96 h) shows cytotoxic to HCT116 and PC‐3 with IC50 values of 0.33 μM and 0.66 μM, respectively[1].
YPC‐22026 (3 μM; 24 h) induces G2/M arrest and decreases the binding of ZNF143 to the STAF binding site[1].
In Vivo:YPC‐22026 (50-100 mg/kg; i.p; on days 1, 2, 3, 8, 9, 12, and 16) significantly inhibits the growth of tumors in the HCT116 xenograft model[1].
In the PC‐3 xenograft model, YPC‐22026 (75 mg/kg; ip) significantly decreases in the intratumoral expression levels of all ZNF143 target genes, RAD51, PLK1, and Survivin[1].
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