Prosaptide Tx14(A)
CAS No. : 196391-82-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $160 | In-stock |
| 5mg | $400 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $980 | In-stock |
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| Cat. No. : | HY-P1342 |
| M.Wt: | 1579.70 |
| Formula: | C69H110N16O26 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2]. In Vitro: Prosaptide Tx14(A) promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].
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