JNJ-DGAT2-A
CAS No. : 1962931-71-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $700 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1650 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110381 |
| M.Wt: | 523.38 |
| Formula: | C24H16BrFN4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C) |
JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1].
IC50 & Target: IC50: 0.14 μM (Sf9 insect cell membranes DGAT2)[1]
In Vitro: JNJ-DGAT2-A (5 μM) inhibits about 99% of recombinant DGAT2 enzymatic activity[1].
JNJ-DGAT2-A (5 μM) inhibits the DGAT activity in HepG2 cell lysates[1].
JNJ-DGAT2-A (0.3125, 0.625, 1.25, 2.5, 5, 10, and 20 µM; 60 min prior to isotope-labeled and additional 2 h after isotope-labeled) dose-dependently inhibits the generation of TG (52:2), TG (54:3), and TG (50:2) using 13C3-D5-glycerol as a substrate in HepG2 cells with IC50 values of 0.85 μM, 0.99 μM, and 0.66 μM, respectively[1].
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