Thalidomide-O-amido-PEG2-C2-NH2


CAS No. : 1957235-74-3

(Synonyms: Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24)

1957235-74-3
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Cat. No. : HY-112617
M.Wt: 462.45
Formula: C21H26N4O8
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1957235-74-3 :

Thalidomide-O-amido-PEG2-C2-NH2 incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer. IC50 & Target: Ligand for E3 Ligase[1]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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