KN-93 (hydrochloride)
CAS No. : 1956426-56-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $145 | In-stock |
| 10mg | $198 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $700 | In-stock |
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| Cat. No. : | HY-15465A |
| M.Wt: | 537.50 |
| Formula: | C26H30Cl2N2O4S |
| Purity: | >98 % |
| Solubility: | H2O : 0.45 mg/mL (ultrasonic;warming);DMSO : ≥ 31 mg/mL |
KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. IC50 & Target: Ki: 370 nM (CaMK-II) In Vitro: After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts[1]. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space[2]. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93[3].
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