IQM-266

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a K_D of 4.63 μM. IQM-266 inhibits the K_V4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD)^[1]. In Vitro:IQM-266 (0-100 μM) concentration-dependently inhibits K_v4.3/DREAM channels (IC₅₀ = 8.6 μM) in CHO cells by slowing their activation and inactivation kinetics^[1].
IQM-266 (0-100 μM) inhibits the maximum peak current and, to a lesser extent, the charge crossing the cell membrane during depolarization at ≥ 10 μM in CHO cells^[1].
IQM-266 (3 μM) increases the charge through the cell membrane during the application of depolarizing pulses, and inhibits peak K_v4.3/DREAM current amplitude while slowing its inactivation in CHO cells^[1].
IQM-266 (3-10 μM) slows the recovery process and increases closed-state inactivation of K_v4.3/DREAM channels in a concentration-dependent manner in CHO cells through its specific interaction with DREAM, which also underlies the observed increase in transmembrane charge^[1].
IQM-266 (3-10 μM) dose-dependently reduces the peak amplitude of IA in rat DRG neurons^[1].