SLF
CAS No. : 195513-96-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $308 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $930 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114872 |
| M.Wt: | 524.65 |
| Formula: | C30H40N2O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
SLF is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF can be used in the synthesis of PROTAC[1][2][3]. In Vitro: Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3].
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