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Galanthamine (hydrobromide)


CAS No. : 1953-04-4

(Synonyms: Galantamine (hydrobromide))

1953-04-4
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Cat. No. : HY-A0009
M.Wt: 368.27
Formula: C17H22BrNO3
Purity: >98 %
Solubility: H2O : 16.67 mg/mL (ultrasonic;warming;heat to 80°C);DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 1953-04-4 :

Galanthamine hydrobromide (Galantamine hydrobromide) is a selective, reversible, competitive, alkaloid AChE inhibitor, with an IC50 of 0.35 µM. Galanthamine hydrobromide is a potent allosteric potentiating ligand (APL) of human α3β4, α4β2, α6β4 nicotinic receptors ( nAChRs). Galanthamine hydrobromide is developed for the research of Alzheimer's disease (AD)[1][2][3]. IC50 & Target:IC50: 0.35 µM (AChE)[3] In Vitro: Galanthamine hydrobromide is 53-fold selectivity for AChE over butyrylcholinesterase[2].
Galanthamine hydrobromide (25-1000 µM) inhibits both Aβ 1-40 (50 µM) and Aβ 1-42 (50 µM) aggregation[4].
Galanthamine hydrobromide (25-1000 µM) protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells[4].
Galanthamine hydrobromide also dramatically reduces Aβ(1-40)-induced cellular apoptosis[4].
In Vivo: Galanthamine hydrobromide (1.25-2.5 mg/kg; i.p. ) reduces cognitive deficits in APP23 mice[5].
Galanthamine hydrobromide (10 mg/kg; i.g.) displays short elimination half-life of approximately 2 h in wild-type mice[6].

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