CD12681
CAS No. : 1952239-59-6
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| Cat. No. : | HY-111366 |
| M.Wt: | 471.61 |
| Formula: | C25H33N3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis[1]. In Vitro: CD12681 (compound 14) shows inhibition with IC50s of 44, >25, 9 µM for CYP 3A4, CYP 2D6, hERG, respectively[1].
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