YF-452
CAS No. : 1951466-83-3
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| Cat. No. : | HY-120200 |
| M.Wt: | 452.39 |
| Formula: | C24H26BrN3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic drug candidate for cancer research[1].
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- YF-452
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- HY-120200
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