Thalidomide-O-amido-C6-NH2
CAS No. : 1950635-13-8
(Synonyms: Cereblon Ligand-Linker Conjugates 11; E3 Ligase Ligand-Linker Conjugates 25)
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| Cat. No. : | HY-112618 |
| M.Wt: | 430.45 |
| Formula: | C21H26N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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