dBET6
CAS No. : 1950634-92-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $92 | In-stock |
| 10mg | $154 | In-stock |
| 25mg | $207 | In-stock |
| 50mg | $333 | In-stock |
| 100mg | $513 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112588 |
| M.Wt: | 841.37 |
| Formula: | C42H45ClN8O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
dBET6 is a highly potent, selective and cell-permeable PROTAC connected by ligands for Cereblon and BET, with an IC50 of 14 nM, and has antitumor activity. IC50 & Target:IC50: 14 nM (BET)[1] In Vitro:dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4[1]. In Vivo:dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL[1].
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