R121919
CAS No. : 195055-03-9
(Synonyms: NBI30775)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $176 | In-stock |
| 25mg | $369 | In-stock |
| 50mg | $590 | In-stock |
| 100mg | $944 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14127 |
| M.Wt: | 380.53 |
| Formula: | C22H32N6 |
| Purity: | >98 % |
| Solubility: | Ethanol : 100 mg/mL (ultrasonic);DMSO : 6.2 mg/mL (ultrasonic) |
R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats[1][2][3].
IC50 & Target:Ki: 2 to 5 nM (CRF1)[1]
In Vitro:R121919 is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types[1].
In Vivo:R121919 (NBI30775) dose dependently decreases adrenocorticopin hormone and Corticosterone (HY-B1618) responses to restraint stress in rats. Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10 mg/kg R121919 are 9 and 25%, respectively[1].
R121919 reduces levels of anxiety in mice with a steep dose-response curve[2].
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