(S,R,S)-AHPC-Me (hydrochloride)
CAS No. : 1948273-03-7
(Synonyms: VHL ligand 2 (hydrochloride); E3 ligase Ligand 1)
| Size | Price | Stock |
|---|---|---|
| 100mg | $24 | In-stock |
| 250mg | $50 | In-stock |
| 1g | $80 | In-stock |
| 5g | $279 | In-stock |
| 10g | $499 | In-stock |
| 25g | $1160 | In-stock |
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| Cat. No. : | HY-42424 |
| M.Wt: | 481.05 |
| Formula: | C23H33ClN4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 63 mg/mL;H2O : 100 mg/mL (ultrasonic) |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. IC50 & Target:Ligand for E3 Ligase[1] In Vitro:The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1].
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