(S,R,S)-AHPC-Me
CAS No. : 1948273-02-6
(Synonyms: VHL ligand 2; E3 ligase Ligand 1A)
| Size | Price | Stock |
|---|---|---|
| 100mg | $45 | In-stock |
| 250mg | $79 | In-stock |
| 1g | $230 | In-stock |
| 5g | $600 | In-stock |
| 25g | $1583 | In-stock |
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| Cat. No. : | HY-112078 |
| M.Wt: | 444.60 |
| Formula: | C23H32N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. IC50 & Target:Ligand for E3 Ligase In Vitro:The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein[1].
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