CL-387785 (Standard)
CAS No. : 194423-06-8
(Synonyms: EKI-785 (Standard); WAY-EKI 785 (Standard))
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| Cat. No. : | HY-10325R |
| M.Wt: | 381.23 |
| Formula: | C18H13BrN4O |
| Purity: | >98 % |
| Solubility: |
CL-387785 (EKI-785; WAY-EKI 785) (Standard) is the analytical standard of CL-387785 (HY-10325). This product is intended for research and analytical applications. CL-387785 is an orally active EGFR inhibitor with an IC50 of 370 pM. CL-387785 inhibits EGF-stimulated EGFR autophosphorylation with an IC50 of approximately 5 nM. CL-387,785 exerts selective inhibition on cell lines overexpressing EGFR or c-erbB-2, whereas it shows weak inhibitory effects on cell lines with low expression of these two receptors. CL-387785 effectively induces cell cycle arrest and apoptosis. CL-387785 can be used for the research of non-small cell lung cancer and autosomal recessive polycystic kidney disease.
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- CL-387785 (Standard)
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