YU238259
CAS No. : 1943733-16-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $52 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $1150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19977 |
| M.Wt: | 459.95 |
| Formula: | C22H22ClN3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
YU238259 is an inhibitor of homology-dependent DNA repair (HDR), used for cancer research. IC50 & Target: HDR[1] In Vitro: YU238259 is an inhibitor of homology-dependent DNA repair, with no effect on PARP activity. YU238259 shows cytotoxicity in BRCA2-deficient cells, with a low LD50 of 8.5 μM. YU238259 (0-5 μM) causes a potent, dose-dependent decrease in HDR efficiency in U2OS DR-GFP or U2OS EJ5-GFP cells, but with no effect on NHEJ frequency. YU238259 (0-10 μM) exhibits synthetic lethality with loss of frequently mutated tumor suppressors, and shows synergism with radiotherapy (IR) and DNA-damaging chemotherapy that is potentiated by BRCA2 loss[1]. In Vivo: YU238259 (3 mg/kg, i.p.) inhibits the growth of BRCA2-deficient tumor xenografts in nude mice[1].
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