ABCG2-IN-3
CAS No. : 1942919-63-2
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| 1mg | $128 | Get quote |
| 5mg | $319 | Get quote |
| 10mg | $550 | Get quote |
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| Cat. No. : | HY-119724 |
| M.Wt: | 451.34 |
| Formula: | C25H20Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1].
In Vitro:ABCG2-IN-3 exhibits a cytotoxicity against cells MDCK II BCRP and MDCK wild-type, with CI50s of 5.82 and 6.55 μM[1].
ABCG2-IN-3 inhibits ATPase with an IC50 of 0.038 μM[1].
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