KMH-233
CAS No. : 1941174-13-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $160 | In-stock |
| 5mg | $480 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1550 | In-stock |
| 50mg | $2400 | In-stock |
| 100mg | $3600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120139 |
| M.Wt: | 587.58 |
| Formula: | C32H25N7O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM)[1].
In Vitro: KMH-233 is able to inhibit binding and transport of essential neutral amino acids and thus, inhibit the cell growth of cancer cells[1].
KMH-233 shows a significant reduction of cell growth with an IC50 of 124 µM[1].
KMH-233 is effective and able to potentiate the anti-proliferative efficacy of Bestatin (100 µM) and Cisplatin (100 µM) at a lower concentration of 25 µM, inhibiting cell growth 53% and 50%, respectively[1].
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