Dihydrocapsaicin


CAS No. : 19408-84-5

19408-84-5
Price and Availability of CAS No. : 19408-84-5
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5mg $38 In-stock
10mg $60 In-stock
25mg $120 In-stock
50mg $190 In-stock
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Cat. No. : HY-N0361
M.Wt: 307.43
Formula: C18H29NO3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 19408-84-5 :

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3]. In Vitro: Dihydrocapsaicin (0-100 μM) inhibits platelet aggregation and the activity of clotting factors VIII:C (6.26-100 μM) and IX (25-100 μM)[3]. In Vivo: Dihydrocapsaicin (0.5 mg/kg, IP, once) exhibits hypothermic effect and neuroprotection in rat MCAO models[2].

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