Triptohypol C
CAS No. : 193957-88-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $310 | In-stock |
| 10mg | $500 | In-stock |
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| Cat. No. : | HY-117469 |
| M.Wt: | 452.63 |
| Formula: | C29H40O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
IC50 & Target:Kd: 0.87 μM (Nur77)[1]
In Vitro:Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin[1].
In Vivo:Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
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