BPHA
CAS No. : 193807-60-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $595 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1290 | In-stock |
| 50mg | $1750 | In-stock |
| 100mg | $2330 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114785 |
| M.Wt: | 396.46 |
| Formula: | C21H20N2O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects[1]. In Vitro:BPHA does not inhibit typical serine proteinases (neutrophil elastase, plasmin, trypsin, and chymotrypsin), cysteine proteinases (cathepsins B and L), aspartic proteinase (HIV-1 protease), or metalloproteinase (aminopeptidase M)[1]. In Vivo:Daily oral administration of 200 mg/kg BPHA in mice results in potent inhibition of tumor-induced angiogenesis, primary tumor growth, and liver metastasis. The growth inhibition activity of BPHA is 48% and 45% in a B16-BL6 melanoma and F2 hemangio-endothelioma model, respectively[1].
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