CMI-392
CAS No. : 193739-23-0
(Synonyms: LDP-392)
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| Cat. No. : | HY-19205A |
| M.Wt: | 633.15 |
| Formula: | C31H37ClN2O8S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively. IC50 & Target:IC50: 100 nM (5-lipoxygenese), 10 nM (PAF)[1] In Vivo: Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED50 for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively[1].
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