Aminoguanidine (hydrochloride)
CAS No. : 1937-19-5
(Synonyms: Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $52 | In-stock |
| 500g | $71 | In-stock |
| 1000g | $137 | In-stock |
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| Cat. No. : | HY-B1041 |
| M.Wt: | 110.55 |
| Formula: | CH7ClN4 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy[1][2][3][4][5].
In Vitro:Aminoguanidine (100, 200, 500, 1000 μM, 24 h) can reduce DOX-induced DNA damage and apoptosis in A549 cells [1].
Aminoguanidine (100 μM, 30 min) can induce ERK activation in AR42J cells and promote cell proliferation [2].
In Vivo:minoguanidine (50 mg/kg, Intraperitoneal injection ) protects mice from CCl4-induced hepatotoxicity[3].
Aminoguanidine (200 mg/kg, Single dose intraperitoneal injection) is protective against cyclophosphamide (CP) -induced oxidative stress and kidney damage in rats[4].br/>
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