BRL-15572 (dihydrochloride)
CAS No. : 193611-72-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $200 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-13200 |
| M.Wt: | 479.87 |
| Formula: | C25H29Cl3N2O |
| Purity: | >98 % |
| Solubility: | H2O : 2 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 250 mg/mL (ultrasonic) |
BRL-15572 dihydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses[1].
IC50 & Target: h5-HT1D[1]
In Vitro: BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells[1].
BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors[1].
In Vivo: BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test[2].
BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig[3].
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